Oble, Julie (2007) New multicomponent reaction with phenols and isocyanides. Thesis, ?? institution/ep ??.
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We have developed the first general N-arylations in Ugi reactions using electron-deficient phenols as acidic components in place of the traditional carboxylic acids. The efficiency of these processes is linked to an irreversible Smiles rearrangement in the last step of the mechanism. Best yields were observed with the highly activated o- and p-nitrophenols, salicylic derivatives giving adducts in lower yields. The scope of these new reactions is further increased by the successful couplings of heterocyclic phenols such as hydroxypyridines and hydroxypyrimidines.
|Item Type:||Thesis (Thesis)|
|Uncontrolled Keywords:||Heterocyclic synthesis|
|Subjects:||Chemistry, Physical Chemistry and Chemical Engineering|
|Deposited By:||Laurence Vidament|
|Deposited On:||09 oct. 2007 02:20|
|Dernière modification:||05 juin 2013 09:13|
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