LOPEZ, Marion (2016) Calcium Signaling in Chondrocytes Undergoing Various Mechano-Chemical Loadings PRE - Research Project, ENSTA.
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Abstract
Calcium signaling is involved in nearly every aspect of cellular life . When a change occurs in the intra-cellular calcium concentration [Ca2+]i, also called cytosolic calcium concentration, it triggers calcium sig- naling. It is, in chondrocytes (cells of the cartilage), one of the first step of mechano-transduction. Various mechano-chemical loadings can generate an influx or an out-flux of calcium in the cell. The purpose of this project was to investigate the effects of different loadings on chondrocytes calcium signaling in vitro. It seems that hyper- and hypo-osmotic loadings result in a transient increase of intra-cellular calcium concentration [Ca2+]i . The transient increase can be followed by oscillations. The hypo-osmotic loading can lead to cell swelling and even cell lyse. Extra-cellular ATP-loading was also studied and it appears that it generates a decrease in the intra-cellular calcium concentration [Ca2+]i.
Item Type: | Thesis (PRE - Research Project) |
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Uncontrolled Keywords: | chondrocytes, calcium signaling, mechano-transduction, hyperosmotic, hypo-osmotic, ATP |
Subjects: | Life Sciences and Engineering |
ID Code: | 6695 |
Deposited By: | Marion Lopez |
Deposited On: | 07 mars 2017 11:10 |
Dernière modification: | 07 mars 2017 11:10 |
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